Ketogenic diet, Fasting Mimicking Diet and Chemotherapy used together to treat aggressive cancer


[Rhonda]: So you were talking about the development
of the fasting-mimicking diet, and how you were looking at all these genetic pathways,
and also you mentioned the ketone bodies and…what was the last thing for… [Valter]: Ketone bodies and glucose. [Rhonda]: And glucose, right. [Valter]: IGF-1, IGFBP-1, glucose, and ketone
bodies. [Rhonda]: And these are all things that regulate
cancer growth as well? [Valter]: Yes, they can regulate cancer, they
do regulate many cancers in different ways. I mean, ketone bodies, you know, some will
argue that they hurt cancer cells, but some cancers actually love to use both ketone bodies
and sugar. [Rhonda]: Yeah, there was a recent publication
I think. [Valter]: So you can actually accelerate cancer
growth with ketone bodies, but you can also hurt cancer cells with ketone bodies. This is why ketogenic diet, you know, I wouldn’t
get too confident about using ketogenic diet alone against cancer cells because of course
even fasting, a lot of cancer cells can adapt to the changed environment. So… [Rhonda]: Yeah, cancer is a very…it’s so…it’s
so complicated when it comes to cancer and it seems like really…you really have to
be careful when you’re trying to treat the cancer. [Valter]: Yeah. And I think that there is a lot of, of course
interest on the ketogenic diets and cancer treatment, and it’s good, I think it can do…there
are situations where the ketogenic diet can hurt the cancer growth. But as for fasting, we see that you need to
have in most cases the powerful target intervention with the fasting. So like fasting and chemo, fasting and kinase
inhibitors, fasting and immunotherapy for example. So, I will assume that the ketogenic diet
alone is going to be a complementary intervention. So now for example we’re very interested in
what happens if you do fasting, ketogenic diet, and cancer treatment together, you know? That I think is very promising. Particularly if you do it in the sense of…And
we have patients that, with very aggressive phenotypes that are doing this. So they do the periodic fasting-mimicking
diet, then in between the ketogenic diet, and then they keep doing the radiotherapy,
and particularly like gliomas, radiotherapies and chemotherapy. And this seems to be working, or certainly
very promising what we’re seeing. [Rhonda]: Is this an ongoing trial you’re
talking about, or is it just… [Valter]: We haven’t started…I mean, we
have trials on cancer, a number of trials on cancer. We don’t have one on glioma yet, but I know
that some groups in Arizona, they are…But then mostly they have just done it with a
ketogenic diet. But because it’s so aggressive, and most people…you
cannot tell like glioma patient, wait until the clinical trial is ready, right? Because it’s a very quick-moving cancer. So, in some cases we just say, look, go to
your oncologist and ask them if they’re okay letting you follow a fasting plus ketogenic
diet plus standard of care. So they’re just adding ketogenic diet and
fasting to the standard of care. [Rhonda]: Yeah, okay. And that’s, so the, for the periodic fasting,
is that also including the fasting-mimicking diet which they can talk to… [Valter]: Yeah. The fasting-mimicking diet, I mean, not water-only
fasting, but FMD, ketogenic diet, and standard of care.